Inositol Side Effects & Adverse Reactions (List) Although high-dose inositol supplementation may attenuate symptoms of a medical condition, many individuals experience unwanted side effects. When taken in large doses, inositol may be an effective treatment for conditions such as: anxiety disorders, depression, eating disorders, hyponatremia, metabolic syndrome, and polycystic ovary syndrome (PCOS). Moreover, inositol plays an integral role in facilitating various biochemical processes including: fat breakdown, gene expression, insulin signal transduction, intracellular calcium (Ca2+) modulation, and nerve cell signaling.ĭespite inositol’s classification as a non-essential nutrient, research suggests that it is likely conducive to general health and well-being. Principally, inositol promotes functioning of signaling molecules and secondary messengers. Since the discovery of inositol in 1849, researchers have elucidated its functional importance within the body. Chemically, there are 9 subtypes of inositol each with distinctive stereoisomers, the most common of which is known as “myo-inositol.” Within the human body, myo-inositol is synthesized from glucose and accounts for 95% of total free inositol content its concentrations are highest within spinal fluid. Inositol is a non-essential nutrient and natural sugar present within phospholipids of cell membranes, plasma lipoproteins, and the nuclei.
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